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Educational paper. The expanding clinical and immunological spectrum of severe combined immunodeficiency.
- Source :
-
European Journal of Pediatrics . May2011, Vol. 170 Issue 5, p561-571. 11p. 1 Color Photograph, 1 Black and White Photograph, 2 Diagrams, 1 Chart, 2 Graphs. - Publication Year :
- 2011
-
Abstract
- Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency characterized by absence of functional T lymphocytes. It is a paediatric emergency, which is life-threatening when recognized too late. The clinical presentation varies from the classical form of SCID through atypical SCID to Omenn syndrome. In addition, there is a considerable immunological variation, which can hamper the diagnosis. In this educational review, we describe the immunopathological background, clinical presentations and diagnostic process of SCID, as well as the therapeutic possibilities. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNODEFICIENCY
*T cells
*LYMPHOCYTES
*PEDIATRIC emergencies
*IMMUNOPATHOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 03406199
- Volume :
- 170
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- European Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 60017461
- Full Text :
- https://doi.org/10.1007/s00431-011-1452-3