Maintenance of early pregnancy without early hormone support after frozen-thawed embryo transfer in hormone replacement treatment cycles

Objective: To report two successful pregnancies after frozen-thawed ET in discontinued hormone replacement treatment cycles. Design: Case report. Setting: University hospital. Patient(s): Two infertile patients. Intervention(s): Hormone replacement treatment for endometrial preparation and frozen-thawed ET. Main Outcome Measure(s): Ovarian ultrasonography, serial hormone measurements of serum E2 and P, successful pregnancy, and follow-up visit. Result(s): One patient discontinued both E2 and P support 2 weeks after ET. The other discontinued estrogen support on the day preceding ET. No spontaneous follicle development was observed by ultrasonography, and no increase in serum P concentration was observed. Both patients became pregnant and achieved deliveries. Conclusion(s): These two cases show that maintenance of pregnancy is possible without early hormone support in hormone replacement treatment cycles. [Copyright &y& Elsevier]