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Treatment regimens with insulin analogues and haemoglobin A1c target of <7% in type 2 diabetes: A systematic review
- Source :
-
Diabetes Research & Clinical Practice . Apr2011, Vol. 92 Issue 1, p1-10. 10p. - Publication Year :
- 2011
-
Abstract
- Abstract: We conducted a systematic review of randomized controlled trials that evaluated the effectiveness of insulin regimens (basal, biphasic, prandial, and basal-bolus) with insulin analogues to reach the haemoglobin A1c target of <7% in patients with type 2 diabetes. We identified 48 trials, with 85 arms and 30,588 patients. There were 38 arms using basal insulin, with 17,588 patients, and a primary outcome of 41.4% (95% CI=35.6–47.4%); 26 arms using biphasic insulin, with 9237 patients, and a primary outcome of 46.5% (40.8–52.3%); 9 arms using prandial insulin, with 1605 patients, and a primary outcome of 39.6% (95% CI, 28.6–51.3%); and 12 arms using basal-bolus insulin, with 2114 patients, and a primary outcome of 53.9% (43.5–64). The high heterogeneity was related, in part, to first time insulin use, final insulin dose, and use of oral drug. The overall incidence of hypoglycaemia ranged from 0 to 4.71 events/patient/30 days; weight gain ranged from 1.75kg for basal to 3kg for biphasic insulin. The HbA1c target of <7% can be achieved in a percentage of type 2 diabetic patients ranging from 40% to 54% depending on the particular insulin regimen. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01688227
- Volume :
- 92
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Diabetes Research & Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 60043907
- Full Text :
- https://doi.org/10.1016/j.diabres.2010.08.006