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Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats
- Source :
-
Environmental Toxicology & Pharmacology . May2011, Vol. 31 Issue 3, p485-489. 5p. - Publication Year :
- 2011
-
Abstract
- Abstract: The toxicokinetic characteristics of naringin were investigated in rats that had been orally administered naringin extract, a candidate for oral treatment of cough, prepared from Citrus grandis “Tomentosa”, at 50, 250, or 1250mg/kg/day in a repeated-dose study for 1, 32, 93, or 184days. Increased values of the mean systemic exposure were approximately proportional to increases in dose levels during all collection intervals; no saturation was observed. No significant differences in mean systemic exposure were observed between male and female rats. Results provide a reference for interpretation of toxicology findings and relevance to clinical safety issues. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 13826689
- Volume :
- 31
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Environmental Toxicology & Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 60082415
- Full Text :
- https://doi.org/10.1016/j.etap.2011.01.006