Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.

Authors :: Elbaz, Alexis
Ross, Owen A.
Ioannidis, John P. A.
Soto-Ortolaza, Alexandra I.
Moisan, Frédéric
Aasly, Jan
Annesi, Grazia
Bozi, Maria
Brighina, Laura
Chartier-Harlin, Marie-Christine
Destée, Alain
Ferrarese, Carlo
Ferraris, Alessandro
Gibson, J. Mark
Gispert, Suzana
Hadjigeorgiou, Georgios M.
Jasinska-Myga, Barbara
Klein, Christine
Krüger, Rejko
Lambert, Jean-Charles
Source :: Annals of Neurology. May2011, Vol. 69 Issue 5, p778-792. 15p.
Publication Year :: 2011
Abstract: The article offers information on a medicine research carried out on independent and joint effects of the MAPT and SNCA genes in Parkinson disease (PD). Independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease were studied. The association between PD and both SNCA SNPs and the H1 MAPT haplotype was confirmed and it was also seen that the joint action of variants in these 2 loci is consistent.