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microRNAs and the Operon Paper
- Source :
-
Journal of Molecular Biology . May2011, Vol. 409 Issue 1, p70-75. 6p. - Publication Year :
- 2011
-
Abstract
- Abstract: The “Operon paper” by F. Jacob and J. Monod started 50 years of research into understanding how the expression of genes is regulated on a molecular level. Ten years ago, microRNAs (miRNAs) emerged as major regulators of eukaryotic gene expression. Here, I will review the basic principles of gene regulation by miRNAs and how these principles can be linked to insights from the Operon paper. A lot of what is understood about miRNAs required a combination of computational and experimental methods. I will discuss some examples that illustrate the power of this approach. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00222836
- Volume :
- 409
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Molecular Biology
- Publication Type :
- Academic Journal
- Accession number :
- 60376551
- Full Text :
- https://doi.org/10.1016/j.jmb.2011.03.021