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The Role of Lipocalin 2 and its Concernment With Human Nonmetastatic Clone 23 Type 1 and p53 in Carcinogenesis of Uterine Cervix.
- Source :
-
Reproductive Sciences . 05/01/2011, Vol. 18 Issue 5, p447-455. 9p. - Publication Year :
- 2011
-
Abstract
- To investigate the novel role of lipocalin 2 and its concernment with human nonmetastatic clone 23 type 1 (nm23-H1) and p53 in cervical carcinogenesis, SiHa cervical cancer cells were knocked down for nm23-H and lipocalin 2 or overexpressed by lipocalin 2 genes. We found that the overexpression of lipocalin 2 or knockdown of nm23-H1 genes increased the proliferation of SiHa cancer cells, while knocking down of lipocalin 2 decreased the proliferation of SiHa. Furthermore, knockdown of nm23-H1 or overexpression of lipocalin 2 was associated with reduced expression of p53 and its downstream gene p21. Using tissue microarrays, lipocalin 2 immunoreactivity was significantly elevated in cancer tissues as compared with it in high- or low-grade dysplasia or normal tissues. Serum secreted form lipocalin 2 from patients with cervical cancer increased in comparison with normal controls. Conclusively, secreted form lipocalin 2 reflects its implication in cervical cancer tissues and may be utilized as an adjuvant biomarker. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *CARCINOGENESIS
*CERVICAL cancer
*GENES
*GENE expression
*DYSPLASIA
Subjects
Details
- Language :
- English
- ISSN :
- 19337191
- Volume :
- 18
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Reproductive Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 60553215
- Full Text :
- https://doi.org/10.1177/1933719110395407