6-month versus 36-month isoniazid preventive treatment for tuberculosis in adults with HIV infection in Botswana: a randomised, double-blind, placebo-controlled trial.

The article presents a study on the effectiveness of extended isoniazid therapy as treatment for tuberculosis in adults with HIV infection in Botswana. The study uses a randomized and placebo-controlled trial in which Cox regression analysis is used to estimate the effect of antiretroviral therapy and compare incident tuberculosis in groups. It is inferred that 36 months' isoniazid prophylaxis is effective for the prevention of tuberculosis than in 6-month prophylaxis in individuals with HIV.