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HLA-DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation.
- Source :
-
Tissue Antigens . Jun2011, Vol. 77 Issue 6, p589-592. 4p. - Publication Year :
- 2011
-
Abstract
- We and others have reported that HLA-DRB1*03 is associated with childhood asthma. To extend this observation and to prove this association, we sensitized and challenged either HLA-DR2 (HLA-DRB1*1502) or HLA-DR3 (HLA-DRB1*0301) transgenic mice with house-dust mite extract. Inflammatory cell counts and cytokine levels in the bronchoalveolar lavage (BAL) fluid between HLA-DR3 and DR2 mice were compared. HLA-DR3 transgenic mice had significantly elevated eosinophil counts, Interleukin-4 and Interleukin-13 levels in the BAL fluid but not interferron gamma-γ. Thus, our study suggests that HLA-DRB1*0301 plays an important role in mounting a Th2-predominant immune response to house dust mite and Th2-type inflammation in the lung. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00012815
- Volume :
- 77
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Tissue Antigens
- Publication Type :
- Academic Journal
- Accession number :
- 60675931
- Full Text :
- https://doi.org/10.1111/j.1399-0039.2010.01617.x