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Time-dependent impact of diabetes on the mortality of patients on renal replacement therapy: A population-based study in Germany (2002–2009)
- Source :
-
Diabetes Research & Clinical Practice . Jun2011, Vol. 92 Issue 3, p380-385. 6p. - Publication Year :
- 2011
-
Abstract
- Abstract: Aims: To estimate the impact of diabetes on the mortality of patients with incident renal replacement therapy (RRT). Methods: We assessed the mortality of 544 incident RRT patients aged ≥30 years between 2002 and 2009 (57.9% men, mean age 70.3 years, 49.6% patients with diabetes) by analyzing the data of all dialysis centers covering a German region. We compared the estimated time-dependent hazard ratios of patients with and without diabetes by using the Cox proportional-hazards regression model. Results: Overall, 319 patients had died (158 diabetic), approximately 50% after 3 years. Up to about 3 years, the mortality rate was lower in diabetic than in nondiabetic patients. Thereafter, the survival curves crossed (interaction diabetes×time, p =0.002; adjusted hazard ratios for diabetes: baseline, 0.66; year 1, 0.84; year 2, 1.05; year 3, 1.33; year 4, 1.68). The results were similar in men and women; however, the interaction of diabetes and time was significant only in men (p =0.004). Further significant risk factors of mortality were age, sex, initial central venous catheter, cardiovascular disease, and malignancy. Conclusions: In this population-based study, the influence of diabetes was time-dependent, with a lower mortality in diabetic versus non-diabetic patients in the first three years but a higher mortality in these patients after 3 years. Results were similar in men and women. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01688227
- Volume :
- 92
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Diabetes Research & Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 61171740
- Full Text :
- https://doi.org/10.1016/j.diabres.2011.02.021