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High throughput cellular screens to interrogate the human T and B cell repertoires
- Source :
-
Current Opinion in Immunology . Jun2011, Vol. 23 Issue 3, p430-435. 6p. - Publication Year :
- 2011
-
Abstract
- There is growing consensus for an urgent need to develop efficient methods to analyze the human T and B cell response in order to understand its regulation, to unravel host-pathogen interactions and to design better vaccines. In this review we will consider different methods that have been developed to analyze human T and B cells and focus in particular on those based on high-throughput cell culture, such as memory B cell immortalization, plasma cell cultures and libraries of naïve or memory T cells. These culture-based methods can be used to interrogate with high efficiency the immune repertoires in order to characterize the frequency, function and specificity of naïve or memory T cells and to isolate potent and broadly neutralizing monoclonal antibodies. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09527915
- Volume :
- 23
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Current Opinion in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 61173485
- Full Text :
- https://doi.org/10.1016/j.coi.2011.04.006