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Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish.
- Source :
-
Annals of Human Genetics . Jul2011, Vol. 75 Issue 4, p516-528. 13p. - Publication Year :
- 2011
-
Abstract
- Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA. DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80. Individuals were grouped into a 13-generation pedigree using the Anabaptist Genealogy Database. A linkage screen of 5944 single nucleotide polymorphisms (SNPs) was performed using 12 informative subpedigrees with an affected-only 2-point and multipoint linkage analysis. Eleven SNPs produced 2-point LOD scores >2, suggestive of linkage. Multipoint linkage analyses, allowing for heterogeneity, detected significant LOD scores on chromosomes 6 (HLOD = 4.50), 7 (LOD*= 3.11), and 14 (HLOD = 4.17), suggesting multiple new loci underlying SA. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00034800
- Volume :
- 75
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Annals of Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 61214407
- Full Text :
- https://doi.org/10.1111/j.1469-1809.2011.00658.x