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Inhibition of HIV-1 integrase by modified oligonucleitides derived from U5′ LTR.

Authors :
Snasel, Jan
Rejman, Dominik
Liboska, Radek
Tocik, Zdenck
Rumi, Tomas
Rosenberg, Ivan
Pichova, Iva
Source :
European Journal of Biochemistry. Feb2001, Vol. 268 Issue 4, p980. 7p. 5 Black and White Photographs, 3 Graphs.
Publication Year :
2001

Abstract

Investigates HIV-1 integrase inhibition by modified oligonucleotides derived from U5′ long-terminal repeat. Determination of the attachment sites to the host DNA; Basis of binding affinity and inhibition activity; Modification of the furanose ring.

Details

Language :
English
ISSN :
00142956
Volume :
268
Issue :
4
Database :
Academic Search Index
Journal :
European Journal of Biochemistry
Publication Type :
Academic Journal
Accession number :
6124581