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Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats.
- Source :
-
Inflammation Research . Jul2011, Vol. 60 Issue 7, p665-672. 8p. 1 Color Photograph, 2 Charts, 3 Graphs. - Publication Year :
- 2011
-
Abstract
- Objective: Green tea proposes anti-inflammatory properties which may attenuate chronic inflammation-induced fibrosis of vessels. This study evaluated whether green tea polyphenols (GTP) can avert fibrosis or vascular disruption along with mechanisms in rats with chronic inflammation. Treatments: Forty 3-month-old female rats were assigned to a 2 (placebo vs. lipopolysaccharide, administration) × 2 (no GTP vs. 0.5% GTP in drinking water) factorial design for 12 weeks. Methods: Masson's trichrome staining evaluated myocardial fibrosis in coronary vessels and surrounding myocardium. Whole blood specimens were counted for differentials. Spleen tumor necrosis factor-α (TNF-α) mRNA expression was determined by real-time RT-PCR. Data were analyzed by two-way analysis of variance (ANOVA) followed by mean separation procedures. Results: After 12 weeks, lipopolysaccharide administration induced myocardial fibrosis in vessels and surrounding myocardium, spleen TNF-α mRNA expression, and leukocytes, while GTP supplementation in drinking water significantly averted such observation. Conclusions: GTP attenuates myocardial fibrosis through a suppression of chronic inflammation and innate immune responses. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEART fibrosis
*GREEN tea
*ANTI-inflammatory agents
*POLYPHENOLS
*LABORATORY rats
Subjects
Details
- Language :
- English
- ISSN :
- 10233830
- Volume :
- 60
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Inflammation Research
- Publication Type :
- Academic Journal
- Accession number :
- 61265864
- Full Text :
- https://doi.org/10.1007/s00011-011-0320-y