ANALYSIS OF INTRINSICALLY DISORDERED REGIONS IN PROTEINS USING RECURRENCE QUANTIFICATION ANALYSIS.

Identification of disordered regions in protein sequence(s) is a very important problem and a long standing puzzle to biologists. In many proteins, these structural disorders (an outcome of improper protein folding) inside an otherwise ordered structure exhibit many important biological functions. Classical approaches to identify these regions in a sequence rely mainly on the pattern recognition algorithms where amino acid residues are classified as ordered or disordered. In this work, we employ recurrence quantification analysis based approach to understand the complex dynamics underlying these regions. We hypothesize and demonstrate that proteins with disordered regions show a strong evidence of the order-chaos-order transition pattern by using windowed recurrence quantification analysis on a database of 476 proteins available from . [ABSTRACT FROM AUTHOR]