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Mild versus strong anti-inflammatory therapy during early sepsis in mice: A matter of life and death.

Authors :
van den Berg, Jan Willem
van der Zee, Marten
de Bruin, Ron W. F.
van Holten-Neelen, Conny
Bastiaans, Jeroen
Nagtzaam, Nicole M. A.
Ijzermans, Jan N. M.
Benner, Robbert
Dik, Willem A.
Source :
Critical Care Medicine. Jun2011, Vol. 39 Issue 6, p1275-1281. 7p. 1 Chart, 5 Graphs.
Publication Year :
2011

Abstract

The article discusses a study on the effectiveness of dexamethasone in varying doses as an anti-inflammatory therapy during early sepsis in mice. The study procedure included the administration of dexamethasone in mice, cecal ligation and puncture, and the administration of phosphate-buffered saline. The researchers concluded that the success of anti-inflammatory therapies in a septic setting is associated to treatment balance.

Details

Language :
English
ISSN :
00903493
Volume :
39
Issue :
6
Database :
Academic Search Index
Journal :
Critical Care Medicine
Publication Type :
Academic Journal
Accession number :
61447867
Full Text :
https://doi.org/10.1097/CCM.0b013e31820edf75