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Organocatalytic Asymmetric Halogenation/Semipinacol Rearrangement: Highly Efficient Synthesis of Chiral α-Oxa-Quaternary β-Haloketones.
- Source :
-
Journal of the American Chemical Society . 6/15/2011, Vol. 133 Issue 23, p8818-8821. 4p. - Publication Year :
- 2011
-
Abstract
- A novel asymmetric halogenation/semipinacol rearrangement reaction catalyzed by cinchona alkaloid derivatives was developed. Two types of β-haloketones (X = Br, Cl) were obtained with up to 95% yield and 99% enantiomeric excess. The desired (+) and (-) enantiomers of the β-haloketones were readily obtained. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HALOGENATION
*CINCHONA alkaloids
*CATALYSIS
*ENANTIOMERS
*ORGANIC chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 133
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 61964385
- Full Text :
- https://doi.org/10.1021/ja201794v