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Merozoite Surface Protein 3 and Protection against Malaria in Aotus nancymai Monkeys.
- Source :
-
Journal of Infectious Diseases . 3/1/2002, Vol. 185 Issue 5, p657. 8p. - Publication Year :
- 2002
-
Abstract
- A blood-stage vaccine based on Plasmodium falciparum merozoite surface protein 3 (MSP3) was tested for efficacy in a primate model. Aotus nancymai monkeys were vaccinated with yeast-expressed MSP3 before a lethal challenge with Plasmodium falciparum parasites. Five of 7 control monkeys had acute infections and required treatment to control parasitemia. Only 1 of 7 monkeys vaccinated with MSP3 required this treatment. The efficacy of the MSP3 vaccination appeared to be comparable to that of MSP142, a leading asexual vaccine candidate, in response to which 2 monkeys experienced acute infections. In the MSP3-vaccinated group, protection correlated with prechallenge titers of antibody to MSP3. In the MSP1 and control groups, protection correlated with antibody to MSP3 raised by challenge infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MALARIA vaccines
*BLOOD proteins
*MONKEY diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 185
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 6209836
- Full Text :
- https://doi.org/10.1086/339187