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Short- to Mid-Term Results Using Autologous Bone-Marrow Mononuclear Cell Implantation Therapy as a Limb Salvage Procedure in Patients With Severe Peripheral Arterial Disease.
- Source :
-
Vascular & Endovascular Surgery . Jul2011, Vol. 45 Issue 5, p398-406. 9p. - Publication Year :
- 2011
-
Abstract
- Short- to mid-term results of a prospective study evaluating dual intramuscular and intra-arterial autologous bone-marrow mononuclear cell (BM-MNC) implantation for the treatment of patients with severe peripheral arterial occlusive disease (PAD) in whom amputation was considered the only viable treatment option are presented. Ankle-brachial indices (ABIs), rest pain, and ulcer healing were assessed at 3 months. Success was defined as improvement in ABI measurements; absence of rest pain; absence of ulcers; and absence of major limb amputations. Twenty patients (21 limbs) have been enrolled. Three-month follow-up evaluation accounting included 18 patients (19 limbs). Four (22.2%) major and 2 (11.1%) minor amputations were performed within 3 months postoperatively. With 17 (94.4%) of 18 limbs demonstrating at least one criterion for success and major amputation avoided in 14 (77.8%) of 18 limbs at the 3-month evaluation, this specific BM-MNC implantation technique is an effective limb salvage strategy for patients with severe PAD. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *ISCHEMIA treatment
*PERIPHERAL vascular disease treatment
*AMPUTATION
*ANALYSIS of variance
*ANGIOGRAPHY
*BONE marrow transplantation
*COMPUTER software
*CONFIDENCE intervals
*FOOT ulcers
*LEG
*LIMB salvage
*LONGITUDINAL method
*HEALTH outcome assessment
*STATISTICS
*T-test (Statistics)
*WOUND healing
*DATA analysis
*PAIN measurement
*TREATMENT effectiveness
*ANKLE brachial index
LEG ulcers
Subjects
Details
- Language :
- English
- ISSN :
- 15385744
- Volume :
- 45
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Vascular & Endovascular Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 62250078
- Full Text :
- https://doi.org/10.1177/1538574411405545