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Reactions with hydrazonoyl halides 62: Synthesis and antimicrobial evaluation of some new imidazo[1,2- a]pyrimidine, imidazo [1,2- a]pyridine, imdazo[1,2- b]pyrazole, and quinoxaline derivatives.

Authors :
Abdelhamid, Abdou O.
Abdelall, Eman K. A.
Zaki, Yasser H.
Source :
Journal of Heterocyclic Chemistry. Mar2010, Vol. 47 Issue 2, p477-482. 6p. 3 Diagrams, 1 Chart.
Publication Year :
2010

Abstract

3-Arylazo-2-(4-methyl-2-phenylthiazol-5-yl)imidazo[1,2-a]pyrimidine, 2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-3-phenylazoimidazo[1,2-a]pyridine, 3-arylazo-2-(4-methyl-2-phenylthiazol-5-yl)-6-phenyl-5Himidazo[1,2-b]pyrazole, 6-(4-methyl-2-phenyl-thiazol-5-yl)-5-phenylazo3-phenyl-imidazo[2,1-b]thiazole, 3-(4-methyl-2-phenylthiazol-5-yl)-2-phenylhydrazino-(1H)-quinoxaline, 3-(4-methyl-2-phenylthiazol-5-yl)- 2-phenylazoquinoxaline, 3-(4-methyl-2-phenylthiazol-5-yl)-2-phenylhydrazinobenzo-[1,4] thiazine, 3-(4-methyl-2-phenyl-thiazol-5-yl)-2-phenylhydrazinobenzo[1,4]oxazine, and 3-(4-methyl-2-phenylthiazol-5-yl)-2-phenylazo-1H-pyrido[2,3-b]pyrazine derivatives were synthesized via reaction of 2-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-2-oxo-N-arylethanehydrazonoyl bromide with each of 2-aminopyrimidine, 2-aminopyridine, 3-aminopyrazoles, 2-amino-4-phenylthiazole, o-phenylenediamine, o-aminothiophenol, o-aminophenol, or 2, 3-diaminopyridine, respectively. All structures of the newly synthesized compounds were elucidated by elemental analysis, spectral data, and alternative synthetic route whenever possible. The entire newly synthesized compounds are tested toward different microorganisms. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0022152X
Volume :
47
Issue :
2
Database :
Academic Search Index
Journal :
Journal of Heterocyclic Chemistry
Publication Type :
Academic Journal
Accession number :
62348502
Full Text :
https://doi.org/10.1002/jhet.307