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In vitro suppression of quercetin on hypertrophy and extracellular matrix accumulation in rat glomerular mesangial cells cultured by high glucose
- Source :
-
Fitoterapia . Sep2011, Vol. 82 Issue 6, p920-926. 7p. - Publication Year :
- 2011
-
Abstract
- Abstract: Quercetin''s protective effects on the glomerulosclerosis of diabetic nephropathy (DN) in rat mesangial cells were investigated. The cell cycles, type IV collagen and laminin, TGF-β1 mRNA, Smad 2/3 and Smad 7, and activities of cell antioxidases were measured. Compared with the high glucose group, quercetin may decrease the cell percentages of G0/G1 phase, Smad 2/3 expression, laminin and type IV collagen, and TGF-β1 mRNA level significantly. The antioxidant capacity, the cell percentages of S phase and Smad 7 expression was significantly increased by quercetin. These results suggest that quercetin is a protective agent against glomerulosclerosis in DN. [Copyright &y& Elsevier]
- Subjects :
- *DIABETIC neuropathies
*ALTERNATIVE medicine
*ANALYSIS of variance
*ANIMAL experimentation
*BIOLOGICAL models
*BIOPHYSICS
*COMPUTER software
*FLOW cytometry
*GINKGO
*GLUCOSE
*KIDNEYS
*RESEARCH methodology
*POLYMERASE chain reaction
*QUERCETIN
*RATS
*RESEARCH funding
*STATISTICAL hypothesis testing
*STATISTICS
*T-test (Statistics)
*WESTERN immunoblotting
*PLANT extracts
*DATA analysis
*OXIDATIVE stress
*REVERSE transcriptase polymerase chain reaction
*PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 82
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 62554984
- Full Text :
- https://doi.org/10.1016/j.fitote.2011.05.001