Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation.

Authors :: Ya-Wen Liu
Neumann, Sylvia
Ramachandran, Rajesh
Ferguson, Shawn M.
Pucadyil, Thomas J.
Schmid, Sandra L.
Source :: Proceedings of the National Academy of Sciences of the United States of America. 6/28/2011, Vol. 108 Issue 26, p10381-10382. 2p.
Publication Year :: 2011
Abstract: The article presents the variation of two similar isoforms of a key enzyme that can offer intrinsic elements of regulation to support tissue-specific functions. It provides a biochemical characterization on Dynamin (Dyn) isoforms such as the Dyn1 and Dyn2 emphasizing that the latter can generate highly curved membranes from flat templates while the former will only self-assemble onto highly curved membrane templates. The five functionally distinct domains consisting Dynamin are also discussed.

Subjects :: *ENZYMES
*BIOCHEMICAL variation
*TISSUE culture
*CELL membranes
*MOLECULAR association

Language :: English
ISSN :: 00278424
Volume :: 108
Issue :: 26
Database :: Academic Search Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 62655208
Full Text :: https://doi.org/10.1073/pnas.1102710108

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