Functional Consequences of Preorganized Helical Structure in the Intrinsically Disordered Cell-Cycle Inhibitor p27Kip1.

Examines the functional consequences of preorganized helical structure in an intrinsically disordered cell-cycle inhibitor. Inhibition of cyclin-dependent kinase activity; Conformation of alpha-helix and beta-structure; Lack of chemical-shift dispersion and negative heteronuclear.