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2-methoxyestradiol induces apoptosis and cell cycle arrest in human chondrosarcoma cells.
- Source :
-
Journal of Orthopaedic Research . Aug2007, Vol. 25 Issue 8, p1106-1114. 9p. - Publication Year :
- 2007
-
Abstract
- 2-Methoxyestradiol (2ME) is an endogenous metabolite with estrogen receptor-independent anti-tumor activity. The current study seeks to determine the mechanism of anti-tumor activity of 2ME on human chondrosarcoma. 2ME caused a time- and dose-dependent cytotoxity in chondrosarcoma cells, while primary chondrocytes were minimally affected. Cells accumulated in G0/G1 phase in response to 2ME and DAPI stain indicated an induction of apoptosis. Bax, Cytochrome C, and Caspase-3 protein expression were increased, while p53 expression was decreased. A higher Bax/Bcl-2 ratio followed 2ME treatment. 2ME has a potentially promising role as a systemic therapy of chondrosarcoma when the mechanism of action is better delineated. Published by Wiley Periodicals, Inc. J Orthop Res 25:1106-1114, 2007 [ABSTRACT FROM AUTHOR]
- Subjects :
- *METABOLITES
*BIOMOLECULES
*ESTROGEN receptors
*TUMORS
*CHONDROSARCOMA
Subjects
Details
- Language :
- English
- ISSN :
- 07360266
- Volume :
- 25
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Orthopaedic Research
- Publication Type :
- Academic Journal
- Accession number :
- 63340192
- Full Text :
- https://doi.org/10.1002/jor.20364