Concomitant information in bioassay and semi-parametric estimation.

This paper presents a flexible modern approach to handling concomitant information for estimating the relative potency parameter in quantitative bioassays. This is accomplished in a semi-parametric framework where the concomitant variable is included non-parametrically. Estimation is then performed using smoothing splines where the point and interval estimators of the relative potency parameter exhibits desirable asymptotic properties. Copyright © 2004 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]