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The Molecular Mechanism of Stabilization of Proteins by TMAO and its Ability to Counteract the Effects of Urea.

Authors :
Qin Zou
Bennion, Brian J.
Daggett, Valerie
Murphy, Kenneth P.
Source :
Journal of the American Chemical Society. 2/20/2002, Vol. 124 Issue 7, p1192. 11p. 4 Color Photographs, 1 Diagram, 5 Charts, 10 Graphs.
Publication Year :
2002

Abstract

Examines the molecular mechanism of stabilization of proteins by trimethylamine n-oxide (TMAO). Solubilities of a homologous series of cyclic dipeptides; Interaction between TMAO solution and the amide unit; Increase of the number of hydrogen bond.

Subjects

Subjects :
*PROTEINS
*OXIDES
*HYDROGEN bonding

Details

Language :
English
ISSN :
00027863
Volume :
124
Issue :
7
Database :
Academic Search Index
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
6384108
Full Text :
https://doi.org/10.1021/ja004206b