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Impact of chemotherapy on health status and symptom burden of colon cancer survivors: A population-based study
- Source :
-
European Journal of Cancer . Aug2011, Vol. 47 Issue 12, p1798-1807. 10p. - Publication Year :
- 2011
-
Abstract
- Abstract: Background: This population-based study assessed the impact of chemotherapy on general and disease-specific health status of resected colon cancer survivors up to 10years post-diagnosis. Patients and methods: Colon cancer survivors diagnosed between 1998 and 2007 were selected from the Eindhoven Cancer Registry. Survivors completed the SF-36 and the EORTC colorectal module (EORTC-QLQ-CR38). Comparisons to a normative population were conducted. Multiple linear regression analyses investigated the association between treatment and health status. Results: Eight hundred and forty eight survivors were evaluated: 29% had chemotherapy (CT); 71% without chemotherapy (nCT). Survivors had similar SF-36 scores and scored better than the normative population on several domains. On the EORTC-QLQ-CR38, male nCT survivors had more sexual problems than CT survivors (p =0.01). Among the sexually active respondents, the survivors reported sex to be less enjoyable than the normative population (p =0.02). In multivariate analyses, CT predicted better physical function, and less male sexual dysfunction and weight loss problems than nCT. Conclusions: Overall, CT survivors have general health status scores comparable to nCT survivors and the normative population up to 10years since initial diagnosis. Sex-related problems among survivors suggest more attention on this often sensitive issue is required in clinical management. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09598049
- Volume :
- 47
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- European Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 63979659
- Full Text :
- https://doi.org/10.1016/j.ejca.2011.02.006