Back to Search
Start Over
Synthesis, crystal structures, electrochemical studies and anti-tumor activities of three polynuclear organotin(IV) carboxylates containing ferrocenyl moiety
- Source :
-
Journal of Organometallic Chemistry . Oct2011, Vol. 696 Issue 20, p3180-3185. 6p. - Publication Year :
- 2011
-
Abstract
- Abstract: A novel ferrocene-containing ligand 3-trifluoromethyl-5-ferrocenyl -pyrazol-1-yl-acetic acid (LCOOH) and three organotin(IV) carboxylate derivatives [Ph4Sn2O(OCH3)(OOCL)]2 (1), [BuSnO(OOCL)]6 (2) and [Bu4Sn2O(OOCL2)2] (3) have been synthesized and structurally characterized by means of FT-IR, elemental analysis, 1H NMR, 119Sn NMR, X-ray crystallography and cyclic voltammetry. Both complexes 1 and 3 are centrosymmetric with ladder framework. Complex 2 is a hexanuclear one with drum structure. Furthermore, their anti-tumor activities were also evaluated, using HepG2 human hepatocellular liver carcinoma cells, A549 human lung carcinoma cells and B16-F10 melanoma cells. Complex 1 displayed the best cytotoxicity and can be pointed out as a promising substrate to be subject of further investigations. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0022328X
- Volume :
- 696
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Journal of Organometallic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 64484130
- Full Text :
- https://doi.org/10.1016/j.jorganchem.2011.06.045