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Risperidone in Ultra Low Dose Protects Against Stress in the Rodent Cold Restraint Model by Modulating Stress Pathways.
- Source :
-
Neurochemical Research . Oct2011, Vol. 36 Issue 10, p1750-1758. 9p. - Publication Year :
- 2011
-
Abstract
- The present investigation evaluates the anti-stress activity of risperidone (RIS) in the cold restraint stress (CRS) model and related stress pathways. Rats were pretreated with RIS (0.1 and 1.0 mg/kg) for 21 days before subjecting to CRS. Ultra low dose of RIS (ULD; 0.1 mg/kg) in contrast to higher dose (1.0 mg/kg) significantly reduced stress in terms of ulcer index. ULD also reversed stress-induced increase in plasma corticosterone and norepinephrine levels used as markers for the function of hypothalamo-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) respectively. ULD caused dose and brain region (hippocampus, prefrontal cortex and striatum) specific changes to stress-induced perturbations of serotonin, dopamine and its metabolites indicating modulation of brain monoaminergic system (BMS). ULD did not show any extrapyramidal side effects. Thus, the anti-stress effect ULD is probably mediated through the HPA axis, SNS and BMS. The study indicates a potential use of ULD in stress disorders. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03643190
- Volume :
- 36
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Neurochemical Research
- Publication Type :
- Academic Journal
- Accession number :
- 64846051
- Full Text :
- https://doi.org/10.1007/s11064-011-0490-6