Non-hemolytic α-AApeptides as antimicrobial peptidomimeticsElectronic supplementary information (ESI) available: Experimental procedures and compound charaterization data. Figures for structures, CD and fluorescence microscopy. See DOI: 10.1039/c1cc13684d

We report a new class of peptide mimetics, α-AApeptides, that display broad-spectrum activity against both Gram-negative and Gram-positive bacteria and fungi. With non-hemolytic activity, resistance to protease hydrolysis, and easy sequence programmability, α-AApeptides may emerge as a novel class of antibiotics. [ABSTRACT FROM AUTHOR]