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Cytochrome P450 3A4-Mediated Oxidative Conversion of a Cyano to an Amide Group in the Metabolism of Pinacidil.
- Source :
-
Biochemistry . 2/26/2002, Vol. 41 Issue 8, p2712. 7p. 4 Diagrams, 4 Graphs. - Publication Year :
- 2002
-
Abstract
- Investigates the influence of cytochrome P450 (CYP) in converting cyano group of pinacidil to the corresponding amide. Incubation of pinacidil with CYP; Results of kinetics of pinacidil amide formation by CYP; Mediation of YCP3A4 reaction.
- Subjects :
- *CYTOCHROMES
*AMIDES
Subjects
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 41
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 6497370
- Full Text :
- https://doi.org/10.1021/bi0119971