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Second-line therapy for castrate-resistant prostate cancer: A literature review.
- Source :
-
Asia Pacific Journal of Clinical Oncology . Sep2011, Vol. 7 Issue 3, p212-223. 12p. - Publication Year :
- 2011
-
Abstract
- Despite a survival benefit in the first-line treatment of castrate-resistant prostate cancer (CRPC) with docetaxel, the prognosis remains limited. There are increasing options available for patients with CRPC in the second-line setting, but there is currently little consensus regarding the optimal treatment. There have been numerous phase II and retrospective studies examining second-line options in CRPC, including retreatment with docetaxel, mitoxantrone, cyclophosphamide and carboplatin, which can be associated with meaningful responses in a significant minority of patients. In 2010 three randomized trials were published or presented which demonstrated a survival benefit in the second-line setting. These included cabazitaxel compared with mitoxantrone, sipuleucel-T (immunotherapy) and abiraterone acetate versus placebo. Ongoing research in the second-line setting of CRPC to optimize treatment options, with the objectives of survival prolongation, improvement in quality of life and pain management, is still needed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17437555
- Volume :
- 7
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Asia Pacific Journal of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 65034590
- Full Text :
- https://doi.org/10.1111/j.1743-7563.2011.01421.x