Assembly of Homolinear α(1→2)-Linked Nonamannoside on Ionic Liquid Support.

An improved method for the synthesis of large and complex oligosaccharides on ionic liquid (LL) support was developed. A strategy to attach the acceptor on IL using a more stable ether linker was used to prevent undesirable decomposition and side products. A "dissolution--evaporation--precipitation" purification procedure was also developed by combining the advantages of precipitation and solid--liquid extraction to reduce mechanical loss and purification time. This approach was successfully used for the rapid assembly of ionic liquid supported homolinear α(1→2)-linked nonamannoside in 25.2% overall yield within 28.5 h. [ABSTRACT FROM AUTHOR]