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Role of p53 gene polymorphism and bladder cancer predisposition in northern India.
- Source :
-
Cancer Biomarkers . 2011, Vol. 8 Issue 1, p21-28. 8p. - Publication Year :
- 2011
-
Abstract
- p53 is a major orchestrator of cellular response to a broad array of stress types by regulating apoptosis, cell cycle arrest, etc. A few polymorphic sites, one at codon72 of exon4, intron3 16bpdel/ins, intron6G>A have been studied with regard to Bladder cancer (BC) risk in North Indians. Genotypes were assessed in hospital-based case-control study comprising of 200BC cases, 265healthy controls. After extraction of genomic DNA from blood, genotyping was done using PCR Restriction Fragment Length Polymorphism. Individuals with p53R72P G>C, CC genotype demonstrated marginally reduced risk of BC (p=0.053, OR=0.29, 95% 16bp-ins/del, [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15740153
- Volume :
- 8
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cancer Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 65201448
- Full Text :
- https://doi.org/10.3233/DMA-2011-0816