Pharmacokinetics of florfenicol in crucian carp ( Carassius auratus cuvieri) after a single intramuscular or oral administration.

Zhao, H.-Y., Zhang, G.-H., Bai, L., Zhu, S., Shan, Q., Zeng, D.-P., Sun Y.-X. Pharmacokinetics of florfenicol in crucian carp ( Carassius auratus cuvieri) after a single intramuscular or oral administration. J. vet. Pharmacol. Therap. 34, 460-463. The pharmacokinetics of florfenicol (FF) was studied in plasma after a single dose (40 mg/kg) of intramuscular (i.m.) or oral gavage (p.o.) administration to crucian carp ( Carassius auratus cuvieri) in freshwater at 25 °C. Ten fish per sampling point were examined after treatment. The data were fitted to two-compartment open models follow both routes of administration. The estimates of total body clearance (CLb), volume of distribution ( Vd/ F), and absorption half-life ( T1/2(ka)) were 0.067 L/h/kg and 0.145 L/h/kg, 2.21 L/kg and 1.04 L/kg, 2.75 and 1.54/h following i.m. and p.o. administration, respectively. After i.m. injection, the elimination half-life ( T1/2(β)) was calculated to be 38.2h, the maximum plasma concentration ( Cmax) to be 16.82 μg/mL, the time to peak plasma FF concentration ( Tmax) to be 1.50 h, and the area under the plasma concentration-time curve (AUC) to be 597.4 μg/mL·h. Following p.o. administration, the corresponding estimates were 2.17 h, 29.32 μg/mL, 1.61 h, and 276.1 μg/mL·h. [ABSTRACT FROM AUTHOR]