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Differential distribution of basement membrane type IV collagen α1(IV), α2(IV), α5(IV) and α6(IV) chains in colorectal epithelial tumors.
- Source :
-
Pathology International . Mar2002, Vol. 52 Issue 3, p224-233. 10p. 30 Black and White Photographs, 3 Charts. - Publication Year :
- 2002
-
Abstract
- In this study, we examined the relationship between the histopathological grade and immunohistochemical localization of six genetically distinct type IV collagen α chains, the major component of basement membrane (BM), in normal and neoplastic colorectal tissues. In the normal colorectal mucosa, α1/α2(IV) and α5/α6(IV) chains were stained in all epithelial BM. However, α3/α4(IV) chains were restrictively immunostained in the BM of the apical surface epithelium. Similar immunostaining profiles for α1/α2(IV) and α5/α6(IV) chains were observed in tubular adenomas with mild/moderate atypia. However, in intramucosal carcinomas, both α1/α2(IV) chains were linearly stained in the BM of cancer cell nests, while the assembly of α5/α6(IV) chains into the BM was inhibited in a discontinuous or negatively stained pattern. The normal colorectal mucosa forms a second network of BM composed of α5/α6(IV), partly α3/α4(IV) chains, in addition to the classic network of α1/α2(IV) chains. The differential immunohistochemical localization of the type IV collagen α5/α6 chains could be one diagnostic marker for the invasiveness of colorectal cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COLLAGEN
*BASAL lamina
*COLON cancer
*PATHOLOGICAL physiology
Subjects
Details
- Language :
- English
- ISSN :
- 13205463
- Volume :
- 52
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Pathology International
- Publication Type :
- Academic Journal
- Accession number :
- 6542369
- Full Text :
- https://doi.org/10.1046/j.1440-1827.2002.01341.x