Cytotoxic Triterpenoid Saponins from the Rhizomes of Anemone taipaiensis.

Two new oleanane-type triterpenoid saponins, 1 and 2, and a new natural product, 3, together with five known saponins, 4-8, were isolated from the rhizomes of Anemone taipaiensis. Their structures were elucidated by extensive spectroscopic analysis and chemical evidences. Six saponins, 1, 2, 4-7, which possessed a free carboxylic group at C-28, exhibited significant cytotoxicity against human leukemia HL-60 cells and human hepatocellular carcinoma Hep-G2 cells with IC50 values in the range of 1.31- 10.12 μM. [ABSTRACT FROM AUTHOR]