Kognityvinių funkcijų vertinimas automatizuota kognityvinių testų baterija CANTABeclipse.

Background. Multiple sclerosis (MS) is an inflammatory demyelinating disorder of central nervous system that is the major course of the disability of young adults. Cognitive dysfunction has negative impact on patients' daily activities, their ability to work, drive, maintain normal social relationships and therefore significantly worsen the patient's quality of life. Patients and methods. A prospective research was performed in Vilnius University Hospital Santariskiu Klinikos Centre of Neurology in 2010 - the first study assessing cognitive function in patients with multiple sclerosis, using an automated computerized neuropsychological test battery CANTAB (Cambridge Neuropsychological Test Automated Battery). There were 20 subjects with clinical definite MS and 20 healthy control subjects participating (>18 years old). Every subject was given CANTAB (Cambridge Neuropsychological Test Automated Battery) tests, evaluating choice response speed, spatial planning, spatial working memory, episodic memory, remembering and working memory capacity. Four cognitive tests were performed: choice reaction time (CRT), spatial span (SSP), Stockings of Cambridge (SOC) and Paired Associates Learning. Results. Choice reaction time: patients 0.431±0.106426 seconds, healthy controls 0.303±0.046620 seconds (p-value 0,000). Healthy persons have made an average of 0.45±0.686 errors per 100, patients have made 1.6± 1.818 errors per 100 (p-value = 0.012). Attention capacity: for patients 5.2±0.696 objects and 6.6± 1.095 objects for healthy controls (p = 0.000). Problems, solved with minimum number of turns: patients 6.74±2.207 problems, healthy controls - 8.15±2.159 problems (p = 0.051). Movements of the figures used to solve problems at all levels: for patients - 18.9868±2.50205 movements, for healthy controls with average 17.2875±2.05560 movements (p = 0.026). Number of errors made in PAL test: patients have made 35.45±38.627 errors, healthy persons 12.55±25.938 errors (p = 0.034). How many of the tasks solved correctly the first time in the PAL test: patients the first time solved 4.95±1.317 tasks, healthy persons 6.35±1.089 tasks (p = 0.001). The total number of times the test was repeated before PAL test was solved correctly: patients 17.1±6.561 times, healthy persons - 11.5±4.059 (p = 0.002). Number of boxes correctly showed immediately after the first presentation in the PAL test: patients - 15.70±5.069, healthy controls - 20.80±3.679 (p = 0.001). The strongest negative statistically significant correlation between EDSS value and attention capacity (correlation coefficient -0.522, p-value = 0.001). Statistically significant negative correlation seen between physical disability and this criterion - the number of tasks correctly solved the first time in the PAL test (correlation coefficient -0.477, p-value = 0.002). The strongest statistically significant correlation seen between duration of disease and reaction rate (r = 0.414, p = 0.008), attention capacity (r = - 0.395, P = 0.012) and the number of tasks correctly solved the first time in the PAL test (r = -0.400, P = 0.011). Conclusions: 1) Cognitive functions in MS patients are significantly worse than in the control group. 2) Cognitive functions rates significantly correlated with physical disability (EDSS scores). The strongest correlation was with attention capacity and speed of reaction. 3) Duration of the disease correlates with these cognitive functions: reaction speed, attention capacity and some rates of episodic memory (there is no strong correlation); duration of disease has no correlation with frontal functions. [ABSTRACT FROM AUTHOR]