Back to Search
Start Over
Molecular mechanisms of liver metastasis.
- Source :
-
International Journal of Clinical Oncology . Oct2011, Vol. 16 Issue 5, p464-472. 9p. - Publication Year :
- 2011
-
Abstract
- Colorectal cancer is the second most common cancer, and is the third leading cause of cancer-related death in Japan. The majority of these deaths is attributable to liver metastasis. Recent studies have provided increasing evidence that the chemokine-chemokine receptor system is a potential mechanism of tumor metastasis via multiple complementary actions: (a) by promoting cancer cell migration, invasion, survival and angiogenesis; and (b) by recruiting distal stromal cells (i.e., myeloid bone marrow-derived cells) to indirectly facilitate tumor invasion and metastasis. Here, we discuss recent preclinical and clinical data supporting the view that chemokine pathways are potential therapeutic targets for liver metastasis of colorectal cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13419625
- Volume :
- 16
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- International Journal of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 66477754
- Full Text :
- https://doi.org/10.1007/s10147-011-0307-2