A common strategy for the stereoselective synthesis of anhydrophytosphingosine pachastrissamine (jaspine B) and N,O,O,O-tetra-acetyl d-lyxo-phytosphingosine

Authors :: Srinivas Rao, G.
Venkateswara Rao, B.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Nov2011, Vol. 52 Issue 46, p6076-6079. 4p.
Publication Year :: 2011
Abstract: Abstract: The highly stereoselective Grignard addition on chiralimine 8 and opening of chiral epoxide 9 with Grignard reagent have been used as key steps in the stereoselective synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B) and N,O,O,O-tetra-acetyl d-lyxo-phytosphingosine. [Copyright &y& Elsevier]

Subjects :: *ORGANIC synthesis
*STEREOCHEMISTRY
*SPHINGOSINE
*AMINES
*GRIGNARD reagents
*ADDITION reactions
*CHIRALITY
*EPOXY compounds

Language :: English
ISSN :: 00404039
Volume :: 52
Issue :: 46
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 66661576
Full Text :: https://doi.org/10.1016/j.tetlet.2011.08.170

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