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CD28 and CILA-4 Have Opposing Effects on the Response of T cells to Stimulation.
- Source :
-
Journal of Immunology . 10/1/2011, Vol. 187 Issue 7, p459-465. 7p. - Publication Year :
- 2011
-
Abstract
- The importance of the B7/CD28/CTLA-4 molecules has been established in studies of antigen-presenting cell-derived 87 and its interaction with the T cell costimulatory molecule CD28. CTLA-4, a T cell surface glycoprotein that is related to CD28, can also interact with B7-1 and 87-2. However, less is known about the function of CTLA-4, which is expressed at highest levels after activation. We have generated an antibody to CTLA-4 to investigate the consequences of engagement of this molecule in a carefully defined system using highly purified T cells. We show here that the presence of low levels of B7-2 on freshly explanted T cells can partially inhibit T cell proliferation, and this inhibition is mediated by interactions with CTLA-4. Cross-linking of CTLA-4 together with the TCR and CD28 strongly inhibits proliferation and IL-2 secretion by T cells. Finally, results show that CD28 and CTLA-4 deliver opposing signals that appear to be integrated by the T cell in determining the response to activation. These data strongly suggest that the outcome of T cell antigen receptor stimulation is regulated by CD28 costimulatory signals, as well as inhibitory signals derived from CTLA-4. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL growth
*ANTIGENS
*T cells
*CELL proliferation
*GLYCOPROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 00221767
- Volume :
- 187
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 66693637