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Total synthesis of radicamine B and 5-epi-radicamine B
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Nov2011, Vol. 52 Issue 48, p6366-6369. 4p. - Publication Year :
- 2011
-
Abstract
- Abstract: Radicamine B 5 was synthesized from p-hydroxy benzaldehyde 7 stereoselectively using acid catalysed amido cyclisation with the help of neighbouring group participation (NGP). Without NGP both radicamine B 5 and its epimer 5-epi radicamine B 6 were obtained. The key steps of the synthesis are Sharpless asymmetric dihydroxylations and acid mediated amido cyclisation. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 52
- Issue :
- 48
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 66944325
- Full Text :
- https://doi.org/10.1016/j.tetlet.2011.09.043