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GRADE guidelines: 9. Rating up the quality of evidence
- Source :
-
Journal of Clinical Epidemiology . Dec2011, Vol. 64 Issue 12, p1311-1316. 6p. - Publication Year :
- 2011
-
Abstract
- Abstract: The most common reason for rating up the quality of evidence is a large effect. GRADE suggests considering rating up quality of evidence one level when methodologically rigorous observational studies show at least a two-fold reduction or increase in risk, and rating up two levels for at least a five-fold reduction or increase in risk. Systematic review authors and guideline developers may also consider rating up quality of evidence when a dose–response gradient is present, and when all plausible confounders or biases would decrease an apparent treatment effect, or would create a spurious effect when results suggest no effect. Other considerations include the rapidity of the response, the underlying trajectory of the condition, and indirect evidence. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 08954356
- Volume :
- 64
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 66945059
- Full Text :
- https://doi.org/10.1016/j.jclinepi.2011.06.004