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Serum prohepcidin levels and iron parameters in term small-for gestational age newborns.
- Source :
-
Journal of Maternal-Fetal & Neonatal Medicine . Dec2011, Vol. 24 Issue 12, p1437-1439. 3p. - Publication Year :
- 2011
-
Abstract
- Aim. To understand the effect of prenatal chronic hypoxia on prohepcidin levels in term newborns. Method. We determined prohepcidin (Pro-Hep) levels in both term appropriate-for-gestational age (AGA) and term small-for-gestational-age (SGA) infants. Uteroplacental insufficiency had exposed all SGA infants to chronic hypoxia. Serum samples were collected from nine full-term SGA infants. Samples were analyzed for complete blood count, serum iron and ferritin concentrations, iron-binding capacity, and prohepcidin levels. Results. The mean serum Pro-Hep level was 156.4 ± 46.7 ng/ml for SGA infants and 482 ± 371.9 ng/ml for 16 healthy term AGA infants (historical controls); this difference was statistically significant. Statistical analyses revealed significant between-group differences for hemoglobin, hematocrit, mean corpuscular volume, red blood cell distribution width, and serum ferritin and Pro-Hep levels. Conclusion. This study showed that compared with AGA infants, Pro-Hep levels were lower in term SGA infants, suggesting that prenatal chronic hypoxia decreases Pro-Hep synthesis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14767058
- Volume :
- 24
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Maternal-Fetal & Neonatal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 67130852
- Full Text :
- https://doi.org/10.3109/14767058.2011.581714