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A Longitudinal Study of GAD65 and ICA512 Autoantibodies During the Progression to Type 1 Diabetes in Diabetes Prevention Trial--Type 1 (DPT-1) Participants.
- Source :
-
Diabetes Care . Nov2011, Vol. 34 Issue 11, p2435-2437. 3p. 1 Graph. - Publication Year :
- 2011
-
Abstract
- OBJECTIVE--We examined changes in GAD65 and ICA-512 autoantibodies (GADA and IA-2A) during progression to type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS--Diabetes Prevention Trial--Type 1 (DPT-1) participants were assessed for changes in positivity and titers of GADA and IA-2A during the progression to T1D. RESULTS--Among 99 progressors to T1D with GADA and IA-2A measurements at baseline and diagnosis (mean interval = 3.3 6 1.5 years), GADA positivity changed little and GADA titers decreased (P < 0.01). In contrast, both IA-2A positivity and titers increased substantially (P < 0.001). Even among those positive at baseline, IA-2A titers increased from baseline to diagnosis (n =5 7; P < 0.001), whereas GADA titers decreased (n=8 0; P < 0.01). The same patterns of change were also evident among those positive for both autoantibodies (n=48) at baseline. CONCLUSIONS--IA-2A titers increase during the years before the diagnosis of T1D, even among those positive for IA-2A. In contrast, GADA titers tend to decline during those years. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIABETES
*AUTOANTIBODIES
*LONGITUDINAL method
*IMMUNOGLOBULINS
*AUTOIMMUNITY
Subjects
Details
- Language :
- English
- ISSN :
- 01495992
- Volume :
- 34
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Diabetes Care
- Publication Type :
- Academic Journal
- Accession number :
- 67184706
- Full Text :
- https://doi.org/10.2337/dc11-0981