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Synthesis and Characterizationof Poly(N-hydroxyethylacrylamide) for Long-Term AntifoulingAbility.
- Source :
-
Biomacromolecules . Nov2011, Vol. 12 Issue 11, p4071-4079. 9p. - Publication Year :
- 2011
-
Abstract
- Development of biomaterials with long-term biocompatibility,durability,and stability remains a critical challenge for biomedical devices.Here, we synthesize, characterize, and graft poly(N-(2-hydroxyethyl)acrylamide) (polyHEAA) onto both gold surfaces andgold nanoparticles (AuNPs) via surface-initiated atom transfer radicalpolymerization (SI-ATRP) to form a stable antifouling coating to resistnonspecific protein adsorption and bacterial attachment. Surface plasmonresonance (SPR) results demonstrate that all of polyHEAA brushes coatedon the gold substrate at a wide range of film thickness of ∼10–40nm can achieve almost zero protein adsorption from undiluted bloodplasma and serum for 1 h, while static bacteria assay results showthat polyHEAA brushes prohibit long-term bacterial colonization by Staphylococcus epidermidisand Escherichia coliRP437up to 3 days. Moreover, the polyHEAA-coated AuNPs withdifferent diameters remain their hydrodynamic sizes unchanged in humanblood plasma and serum for up to 7 days. All these data indicate thatpolyHEAA can serve as promising biomaterials with long-term biocompatibilityand durability suitable for applications in complex biological media. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15257797
- Volume :
- 12
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Biomacromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 67187702
- Full Text :
- https://doi.org/10.1021/bm2011455