Transition Metals in Organic Synthesis, Part 96.1 First Total Synthesis of Streptoverticillin: Unambiguous Confirmation of the Absolute Configuration.

Using an iron-mediated construction of the carbazole framework, the first synthesis of streptoverticillin is described and the absolute configuration of the natural product is confirmed. The synthesis exploits a novel oxygen-mediated aromatization of tricarbonyliron-coordinated dihydrocarbazoles. Moreover, non-natural (R)-streptoverticillin is prepared for comparison. [ABSTRACT FROM AUTHOR]