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HCV and the hepatic lipid pathway as a potential treatment target
- Source :
-
Journal of Hepatology . Dec2011, Vol. 55 Issue 6, p1428-1440. 13p. - Publication Year :
- 2011
-
Abstract
- Atherosclerosis has been described as a liver disease of the heart . The liver is the central regulatory organ of lipid pathways but since dyslipidaemias are major contributors to cardiovascular disease and type 2 diabetes rather than liver disease, research in this area has not been a major focus for hepatologists. Virus–host interaction is a continuous co-evolutionary process involving the host immune system and viral escape mechanisms . One of the strategies HCV has adopted to escape immune clearance and establish persistent infection is to make use of hepatic lipid pathways. This review aims to: [•] update the hepatologist on lipid metabolism [•] review the evidence that HCV exploits hepatic lipid pathways to its advantage [•] discuss approaches to targeting host lipid pathways as adjunctive therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01688278
- Volume :
- 55
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 67321641
- Full Text :
- https://doi.org/10.1016/j.jhep.2011.06.004