Fully substituted unsaturated lactones from endophytic Myrothecium sp.

Two new α,β-unsaturated γ-lactones, myrolactones A (1) and B (2), were characterized from the culture broth of the Myrothecium sp. IFB-E106 isolated from the roots of Vatica mangachapoi Blauco. The absolute configuration was determined by the computational electronic circular dichroism approach. Myolactone B showed neuraminidase inhibitory activity with the IC50 value of 13.95 μM. [ABSTRACT FROM AUTHOR]