Isolation and characterization of secondary metabolites from Plumeria obtusa.

Chromatographic purification of the methanolic extract of Plumeria obtusa yielded two new iridoid obtusadoids A (1) and B (2), along with eight known compounds plumieridin A (3), plumieridine (4), 1α-plumieride (5), 15-demethylplumieride (6), rel-(3R,3′S,4R,4′S)-3,3′,4,4′-tetrahydro-6,6′-dimethoxy[3,3′-bi-2H-benzopyran]-4,4′-diol (7), glochiflavanoside B (8), oleanolic acid (9), and methyl coumarate (10). The structures of all the isolates (1–10) were determined by NMR spectroscopy and mass spectrometry. The data of known compounds (3–10) were further compared with the reported data for these compounds. [ABSTRACT FROM PUBLISHER]